Cope rearrangement solved problems

This chapter has attempted to demonstrate how secondary deuterium and tritium KIEs can be used to elucidate the mechanisms of reactions and determine the structure of their transition states. In particular, the advantages of using both theoretical calculations and experimental data to solve these problems has been emphasized. Unfortunately, several important topics where the combination of theoretical calculations and experimental work has been very useful in extending our understanding of KIEs could not be discussed. In particular, the extensive studies on the Diels-Alder and the Cope rearrangement by Houk and co-workers (Beno et al., 1996 Houk et al., 1992 Storer et al., 1994) are noteworthy. 

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