Coordination of Purine and Pyrimidine Nucleotide Biosynthesis

A balanced synthesis of pyrimidine and purine nucleotides is essential for the biosynthesis of nucleic acids in growing cells. Several mechanisms exist for coordinating nucleotide synthesis. 

PRPP affects purine and pyrimidine nucleotide biosynthesis. PRPP formation is activated by inorganic phosphate and inhibited by several end products of pathways that use PRPP. In the purine de novo pathway, PRPP activates amidophosphoribosyltransferase and is the rate-limiting substrate for the enzyme. In purine 

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