Cooperativity in Binding DAO or DAAO D-Amino Acid Oxidase

Cooperativity in Binding DAO or DAAO D-Amino Acid Oxidase 

A number of recent publications have highlighted that fragment-type molecules can bind with extraordinary ligand efficiencies to D-amino acid oxidase (DAO). A representative set of fragments showed LEs of 0.95 kcal/mol [102], which 

1 Bohm, H.-J. and Klebe, G. (1996) What can we learn from molecular recognition in protein-ligand complexes for the design of new drugs Angewandte Chemie Intematioruil Edition in English, 35, 2588-2614. 

3 Chaires, J.B. (2008) Calorimetry and thermodynamics in drug design. Annual Review of Biophysics, 37,135-151. 

4 Holdgate, G.A. and Ward, W.H.J. (2005) Measurements of binding thermodynamics in drug discovery. Drug Discovery Today, 10,1543-1550. 

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Cooperativity in Binding DAO or DAAO D-Amino Acid Oxidase 393 Table 13.8 Representative set of extremely ligand efficient DAO fragment binders [102]. 

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