Convulsion vincristine

Johnson and colleagues have summarized the major toxicological observations made after administration of vinblastine or vincristine to other animals Ib). In rabbits and cats intravenous doses of 0.2 mg/kg vincristine were lethal after the second to the fifth dose on a schedule involving drug administration two to three times a week. Signs consistent with neurotoxicity were observed in rabbits and cats for example, a head drop phenomenon, characteristic of neuromuscular dysfunction, was observed in rabbits, and clonic convulsions were observed in cats. Vincristine is lethal to dogs when administered at 0.05 mg/kg, intravenously, five times in a 1-week period. Vincristine is lethal to monkeys when administered five times on a schedule of 1 mg/kg weekly comparable toxicity is observed when the drug is administered more frequently (daily) at lower doses (e.g., 0.2 g/kg). 

An 8-year-old girl with leukemia had tonic-clonic convulsions and life-threatening encephalopathy after intravenous vincristine. After the second dose (1.5 mg/m in combination with prednisone) she developed seizures and bilateral translucencies in the CT scan. When vincristine was withdrawn in subsequent cycles, the symptoms disappeared (61). 

Symptoms Blurred Vision, Deafness, Symptoms Convulsions/Seizures, Vincristine... 

Frappaz D, Biron P, Biron E, Amrane A, Philip T, Brunat-Mentigrty M. Toxicite neurologique severe (coma, convulsions, neuropathic motrice distale) secondaire a I association d une intoxication accid telle a I isoniazide (ENH) et d un protocole comportant de fortes doses de vincristine (VCR). Pediatrie (1984) 39,133-40. 

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