Conversion into amides

Acyl hahdes may be identified by —hydrolysis to the corresponding acids (the latter may be further characterised as in Section IV,175) conversion into amides (Section IV,191), anihdes or p-toluidides (Section IV,100) and conversion into sohd esters (Section IV,183). 

Macrocyclic diether derivatives, (IV), prepared by Chen (5) were also effective as NS3 serine protease inhibitors of the hepatitis C virus after conversion into amide derivatives using Intermediate Amines described in Table 3. 

COO-Na i C2H5OH Sodium benzoate Ethyl alcohol (b) Conversion into amides. Ammonolysis. Discussed in Sec. 20.19. 

Similarly 8-hydroxy rather than 11-hydroxy structures have been demonstrated for alangicine and alangimarckine (417) by synthesis from the ester prepared as an intermediate in the synthesis of ankorine, by conversion into amides of 3-benzyl-oxy-4-methoxypheny1ethyl amine and tryptamine respectively, followed by Bischer-Napieralski ring closures (T. Fujii et al.. Tetrahedron Letters, 1976, 2553 1977, 3477 1978, 3111). 

Two-stage single-pot derivatization of carboxylic acids (with intermediate formation of chloroanhydrides with thionyl chloride followed by their conversion into amides) was recommended preferably for HPLC analysis, but the simplest dialkylamides and even anilides ° are volatile enough for GC analysis also (the mixture of PhaP and CCLt, instead of SOCI2, can be used in this reaction). Moreover, the same procedure is used for the synthesis of diastereomeric derivatives of enantiomeric carboxylic acids (see below) ... 

An important reaction of oximes (e.g. R2C = NOH) is their conversion into amides (e.g. RCONHR) in the Beckmann rearrangement reaction. 

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