Convergent Methods for the Synthesis of Glycopeptide-Thioesters

Glycosyl amine, HBTU, HOBt, DIPEA, DMSO 

SCHEME 11.4 Convergent concept demonstrated by the Lansbury group. Bn, benzyl cHex, cyclohexyl DIPEA, diisopropylethylamine DMSO, dimethyl sulfoxide DNP, 2,4-dinitrophenyl HBTU, 2-(l//-benzotriazol-l-yl)-l,l,3,3-tetramethyluronium hexafluorophosphate HOBt, 1-hydroxybenzotriazole Ts, tosyl. 

SCHEME 11.5 Efficient concept for convergent method using the pseudoproline scaffold reported by (a) Unverzagt et al. and (b) Danishefsky et al. BMP, butyl-3-mercaptopropionate DIC, diisopropylcarbodiimide DMF, /V,/V-di methyl form amide Gly, glycine HATU, 

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