Convergent fragment coupling synthesi

JC Hendrix, JT Jarrett, ST Anisfield, PT Lansbury. Studies related to a convergent fragment-coupling approach to peptide synthesis using the Kaiser oxime resin. J Org Chem 57, 3414, 1992. 

C.H. Heathcock and co-workers devised a highly convergent asymmetric total synthesis of (-)-secodaphniphylline, where the key step was a mixed Claisen condensation. In the final stage of the total synthesis, the two major fragments were coupled using the mixed Claisen condensation] the lithium enolate of (-)-methyl homosecodaphniphyllate was reacted with the 2,8-dioxabicyclo[3.2.1]octane acid chloride. The resulting crude mixture of (3-keto esters was subjected to the Krapcho decarboxylation procedure to afford the natural product in 43% yield for two steps. 

In general, the aforementioned fragment coupling strategy, one-pot reaction method and step-by-step non-convergent synthesis provide useful and... 

Sasaki, M., Ishikawa, M., Fuwa, H., and Tachibana, K. (2002) A general strategy for the convergent synthesis of fused polycyclic ethers via B-alkyl Suzuki coupling synthesis of the ABCD ring fragment of ciguatoxins. Tetrahedron, 58,1889-1911. 

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