Conus textile, conotoxins

Rigby AC, Lucas-Meunier E, Kalume DE, Czerwiec E, Hambe B, Dahlqvist I, Fossier P, Baux G, Roepstorff P, Baleja JD, Furie BC, Furie B, Stenflo J (1999) A Conotoxin from Conus textile with Unusual Posttranslational Modifications Reduces Presynaptic Ca+2 Influx. Proc Natl Acad Sci USA 96 5758... 

Kalume DE, Stenflo J, Czerwiec E, Hambe B, Furie BC, Furie B, Roepstorff P (2000) Structure Determination of Two Conotoxins from Conus textile by a Combination of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight and Electrospray Ionization Mass Spectrometry and Biochemical Methods. J Mass Spectrom 35 145... 

Conotoxins with the co-type 6-Cys/4-loop framework (C—C—CC—C—-C) are the most abundant group of peptides isolated from Conus venoms so far. This structural class encompasses at least four known pharmacological classes co-conotoxins that block voltage-sensitive calcium channels, 5-conotoxins that retard sodium channel inactivation, the sodium channel blocker conotoxin-GS, and two peptides recently found in C. marmoreus that affect both sodium and calcium currents. In addition, three co-type 6-Cys/4-Ioop peptides with still unknown targets have been found in C. textile (Cruz et al., 1992) and C. quercinus (Abogadie et al., 1990 Olivera et al., 1990). 

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