Conus radiatus

Nondisulfide-rich single S-S Contryphans Contryphan-R GCOWEPWC Conus radiatus P TBD... 

The octapeptide bromocontryphan (63) is a constituent of the venom of Conus radiatus [115]. While this small peptide has many of the structural features of a marine natural product, Olivera and co-workers have recently provided evidence that this compound is the result of the direct translation of a gene [115]. Thus, bromocontryphan is not a true natural product but has been included in this chapter based on its structure and the lessons that can be learned from a careful analysis of a compound s metabolic origin. The peptide is translated from mRNA as a... 

White, H.S., McCabe, R.T., Armstrong, H Donevan, S.D., Cruz, L.J., Abogadie, E.C., Tores, J., Rivier, J.E., Paarmann, I., Holbnann, M., and Olivera, B.M. (2000) In vitro and in vivo characterization of conantokin-R, a selective NMDA receptor antagonist isolated from the venom of tiie fish-hunting snail Conus radiatus. J. Pharmacol. Exp. Ther, 292, 425-432. 

Craig, A.G., Jimenez, E.C., Dykert, J., Nielsen, D.B., Gulyas, J., Abogadie, F.C., Porter, J., Rivier, J.E., Cruz, L.J., Oliveras, B.M., and McIntosh, J.M. (1997) A novel post-translational modification involving bromination of tryptophan identification of the residue, L-6-bromotryptophane, in peptides from Conus imperialis and Conus radiatus venom. J. Biol. Chem., 272, 4689-4698. 

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