Controlled drug delivery hydrogel polymers

Zhang Z, Chen L, Zhao CW, Bai YY, Deng MX, Shan HL, Zhuang XL, Chen XS, Jing XB (2011) Thermo- and pH-responsive HPC-g-AA/AA hydrogels Pot controlled drug delivery applications. Polymer 52 676-682... 

Huang YJ, Liu MZ, Gong QY, et al. A novel magnetic triple-responsive composite semi-lPN hydrogels for targeted and controlled drug delivery. Eur Polym J October 2012 48 1734-44. 

In the last few years there have been new creative methods of preparation of novel hydrophilic polymers and hydrogels that may represent the future in drug delivery applications. The focus in these studies has been the development of polymeric structures with precise molecular architectures. Stupp et al. (1997) synthesized self-assembled triblock copolymer, nanostructures that may have very promising applications in controlled drug delivery. Novel biodegradable polymers, such as polyrotaxanes, have been developed that have particularly exciting molecular assemblies for drug delivery (Ooya and Yui, 1997). 

Korsmeyer, R.W. (1990) Diffusion controlled systems hydrogels in Polymers for Controlled Drug Delivery (ed. P.J. Tarcha), CRC Press, Boca Raton, p. 15. 

Mohamadnia, Z., Zohuriaan-Mehr, A.J., Kabiri, K. et al. 2007. pH-sensitive IPN hydrogel beads of carrageenan-alginate controlled drug delivery. J Bioact Compat Polym. 22 342-356. 

The reversible nature of DNA hybridization in response to an external stimulus causes this type of DNA-polymer hydrogels to have special properties, such as sol-gel phase transition and responsive releasing capability [93]. Thus, potential applications of these materials as label-free DNA sensing device or for controlled drug delivery have been discussed. Just a small portion of DNA is needed to achieve hydrogel responsiveness. 

Z. Mohamadnia, M. J. Zohuriaan-Mehr, K. Kabiri, A. Jamshidi and H. Mobedi, pH-Sensitive IPN Hydrogel Beads of Carrageenan-Alginate for Controlled Drug Delivery /. Bioact. Compat. Polym. 22, 342-356 (2007). 

Shalviri A, Liu Q, Abdekhodaie MJ, Wu XY. Novel modified starch-xanthan gum hydrogels for controlled drug delivery synthesis and characterization. Carbohydr Polym. 2010 79(4) 898-907. 

Rossi, F., Ferrari, R., Castiglione, F., Mele, A., Perale, G., MoscateUi, D., 2015b. Polymer hydrogel functionalized with biodegradable nanoparticles as composite system for controlled drug delivery. Nanotechnology 26, 015602. 

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