Controlled chronic safety data

It has been suggested that treatment with supraphysiologic levels of iodine has potential therapeutic uses beyond thyronine function (Miller, 2006). Some clinicians believe that all tissues in the human body should be saturated with iodine (Flechas, 2005). Maintenance of the equilibrium between thyroidal and extrathyroidal iodine is estimated to require about six times the tolerable upper intake level (UL) (Berson and Yalow, 1954). Controlled chronic safety data for daily iodine intake at these levels are difficult to find even though physicians prescribed daily iodine therapy at doses that ranged from 10 to 100 times the UL during the first half of the twentieth century (Kelly, 1961). 

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