Continuous separation microseparators

Despite the advantages of CEC over CE and HPLC, particle-packed columns are plagued with problems such as the difficulty in the preparation of frits to retain the stationary phase and bubble formation that results in current leakage and EOF breakdown. These problems set the pace for the development of column technology to overcome the problems associated with particle-packed columns and to improve on the speed of separation of analytes in mixtures. The fabrication of a continuous porous rod (monoliths), not requiring any frits and ensuring a constant and uniform current flow to give a stable EOF has so far proved a potential development for microseparations. ... 

The group of Jensen has designed microseparators to perform Hquid-hquid extraction and to separate liquid and gas phases. Both selfiassembled microfluidic extraction systems were used in continuous multi-step syntheses of carbamates 62 from acid chlorides 61 without isolation and storage of the intermediate azides and isocyanates (Scheme 15) (2007AGI5704). 

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