Continuous dual reaction kinetics

Scheme 10.16 Schematic diagram of continuous flow dual reaction kinetics. The dual reaction system consists of two nickel-derivatized silica microreactors connected in series as described in Section 2.3.4. His6-enzymes transketolase and transaminase were immobilized inside each of the microreactors...

Hie medicinal chemist used n-butyllithium on a very small scale and there was no problem producing the lidiium salt 1. This was then reacted with the appropriate benzaldehyde 2 in methyl t-butyl ether to make the required benzhydrol 3. Based on the kinetics of this reaction and die reactivity of the final product 3, a continuous reaction reactor system (Figure S) was made of 3/8 inch pipe fed by dual head pun s such that 1 was reacted immediately with 2. 

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