Context-sensitive half time

The use of compartmental models leads onto the subject of context-sensitive half time (CSHT). 

Figure 2.8 Context-sensitive half-times for some intravenous anaesthetic drugs. Note the different half-time scale for die two panels.

Hughes MA, Glass PS, Jacobs JR. Context-sensitive half-time in multicompartment pharmacokinetic models for intravenous anesthetic drugs. Anesthesiology 1992 76 334—41. 

Duration is dependent on a context-sensitive half-time of 3-4 minutes. 

Table 7-3 shows the BMDs and BMDLs for the five principal Faroe Islands outcomes based on cord-blood measurements. Normally, the most sensitive adverse end point is selected as the basis for risk assessment. However, in the context of a neuropsychological test battery, the reliability of the individual end points can be highly variable. Therefore, it might not be appropriate in all cases to select the one most sensitive end point as a point of departure for the BMDS. In the Faroe Islands cord-blood analyses, the CPT reaction time measure had the smallest BMD and BMDL. However, because of difficulties in test administration, the data from the second half of the cohort were discarded for the analysis of this end point. Under the circumstances, the committee felt that it would be more appropriate to select the second most sensitive end point, the Boston Naming Test, for which no administiation difficulties were encountered. It is noteworthy that the Boston Naming Test... 

---