Containers insulin adsorption

The ability of some macromolecules to adsorb at interfaces is made use of in suspension and emulsion stabilisation (see Chapter 7). Gelatin, acacia, poly(vinyl alcohol) and proteins adsorb at interfaces. Sometimes such adsorption is unwanted, as in the case of insulin adsorption onto glass infusion bottles and poly(vinyl chloride) infusion containers and tubing used in giving sets. Adsorption of insulin to glass bottles and plastic i.v. tubing at slow rates of infusion is well documented. It... 

Surface Adsorption. Adhesion of proteins to surfaces is a well-known phenomenon. The denatured or I states of the protein expose hydrophobic domains. This exposure promotes the binding of the protein to the walls of the container and other surfaces it comes in contact with. It has been well documented that insulin binds to surfaces of delivery pumps, to glass and plastic containers, and to the inside of the intravenous bags [15]. 

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