Constitutive androstane receptor regulation

Maglich JM, Stoltz CM, Goodwin B, Hawkins-Brown D, Moore JT, Kliewer SA. Nuclear pregnane X receptor and constitutive androstane receptor regulate overlapping but distinct sets of genes involved in xenobiotic detoxification. Mol Pharmacol 2002 62 638-646. 

In addition to PXR, the expression of UGT1A1 and several other UGT isoforms have also been reported to be regulated by several other nuclear receptors, including constitutive androstane receptor (CAR) [25,27,28] and peroxisome proliferator activated receptor a (PPARa) [29,30],... 

Kast, H.R., Goodwin, B., Tarr, P.T., Jones, S.A., Anisfeld, A.M., Stoltz, C.M., Tontonoz, P., Kliewer, S., Willson, T.M. and Edwards, P.A. (2002) Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. Journal of Biological Chemistry, 277, 2908-2915. 

O. Burk, K.A. Arnold, A. Geick, H. Tegude, and M. Eichelbaum. A role for constitutive androstane receptor in the regulation of human intestinal MDR1 expression. Biol Chem. 386 503-513 (2005). 

Ferguson SS, LeCluyse EL, Negishi M, Goldstein JA. Regulation of human CYP2C9 by the constitutive androstane receptor discovery of a new distal binding site. Mol Pharmacol 2002 62 737-746. 

Kast HR, Goodwin B, Tarr PT, et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, famesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 2002 277 2908-2915. 

Pascussi JM, Gerbal-Chaloin S, Fabre JM, Maurel P, Vilarem MJ. Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes Consequences on cytochrome P450 gene regulation. Mol Pharmacol 2000 58 1441-50. 

Malaplate-Armand, C., Ferrari, L., Masson, C., Visvikis-Siest, S., Lambert, H. and Batt, A.M. (2005) Down-regulation of astroglial CYP2C, glucocorticoid receptor and constitutive androstane receptor... 

Tien, E.S., Matsui, K., Moore, R. and Negishi, M. (2007) The nuclear receptor constitutively active/androstane receptor regulates type 1 deiodinase and thyroid hormone activity in the regenerating mouse liver. The Journal of Pharmacology and Experimental Therapeutics, 320, 307-313. 

Echchgadda, I., Song, C. S., Oh, T., Ahmed, M., De La Cruz, I. J., and Chatterjee, B. (2007) The xenobiotic-sensing nuclear receptors pregnane X receptor, constitutive androstane receptor, and orphan nuclear receptor hepatocyte nuclear factor 4alpha in the regulation of human steroid-/bile acid-sulfotransferase. Mol. Endocrinol. 21, 2099-2111. 

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