Constitutional Factors Affecting the Reactivity of Functional Groups

2 CONSTITUTIONAL FACTORS AFFECTING THE REACTIVITY OF FUNCTIONAL GROUPS 

FIGURE 6.1 Constitutional factors affecting the reactivity of functional groups. (A) The reactivity of W depends on the location of the residue. (B) The amino group of a dipeptide ester reacts with the ester carbonyl to form a cyclic dipeptide amino groups of other peptide esters do not react in this manner. (C, D) Reactions between residues of identical configuration do not occur at the same rates as reactions between residues of opposite configuration. 

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