Constipation ranolazine

The most common adverse effects are dizziness, headache, constipation, and nausea. Ranolazine should be started at 500 mg twice daily and increased to 1,000 mg twice daily if needed based on symptoms. Baseline and followup ECGs should be obtained to evaluate effects on the QT interval. 

Ranolazine Inhibits late sodium current in heart also may modify fatty acid oxidation Reduces cardiac oxygen demand fatty acid oxidation modification may improve efficiency of cardiac oxygen utilization Prophylaxis of angina Oral, duration 6-8 h Toxicity QT interval prolongation, nausea, constipation, dizziness Interactions Inhibitors of CYP3A increase ranolazine concentration and duration of action... 

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