Dissociation equilibrium constant constant

Initial substrate concentration Unimolecular rate constant for mechanism step n Bimolecular rate constant for mechanism step n Michaelis constant Equilibrium dissociation constant for ES complex... 

Table 3. Equilibrium Dissociation Constants for Drug—Receptor Complexes In Vitro...

Affinity is the strength of binding of a drag to a receptor. It is quantified by an equilibrium dissociation constant. 

Converting to equilibrium dissociation constants (i.e., Kd = 1/Ka) leads to the equation... 

It can be seen that the equality defined in Equation 4.32 is true only when ICSo = KB (i.e., the concentration of a non-competitive antagonist that reduces the binding of a tracer ligand by 50% is equal to the equilibrium dissociation constant of the antagonist-receptor complex). 

The equilibrium dissociation constant of the agonist-receptor complex (Ka) can be obtained by a regression of 1/[A] upon 1/[A7]. This leads to a linear regression from which... 

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