Consilient mechanisms diverse

A diverse set of energy conversions that sustain life can be experimentally demonstrated by de novo design of elastic-contractile model proteins under the precept of a single, pervasive, mechanism, that is, by a consilient mechanism that creates a common groundwork of explanation. It is a mechanism that achieves function by controlling association of... [Pg.5]

Consilient Mechanisms for Diverse Protein-based Machines The Efficient Comprehensive Hydrophobic Effect... [Pg.102]

A Consilient Mechanism Provides a Common Groundwork of Explanation for the Diverse Energy Conversions of Biology... [Pg.103]

The position of the T,-divide that separates soluble from insoluble (hydrophobically associated) states in the phase diagram depends on seven variables on the six intensive variables of temperature, chemical potential, electrochemical potential, mechanical force, pressure, and electromagnetic radiation, and on polymer volume fraction or concentration. Therefore, diverse protein-catalyzed energy conversions by the consilient mechanism result from designs that control the location of the Tfdivide in this seven-dimensional phase transitional space. Complete mathematical description has yet to be written for representation of the T,-divide in seven-dimensional phase transitional space, but it may prove to be more relevant to... [Pg.124]