Connective tissue extracellular matrix integrins

The mineralized matrix of bone tissue is strained when loaded. Macro-molecular mechanical connections between the extracellular matrix and the osteocytic cell membrane exist and these connections may be capable of transmitting information from the strained extracellular matrix to the bone cell nuclear membrane. The basis of this mechanism is the physical continuity of the transmembrane integrin molecule, which is connected extracellularly with the macromolecular collagen of the organic matrix and intracellularly with the... 

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