Conjugation TCDD metabolism

Hydroxy-l,3,7,8-TCDD was found to be the major metabolite of 2,3,7,8-TCDD in dogs but not in rats (Poiger et al. 1982). The metabolites from dogs administered to rats were eliminated as conjugates in the bile (Weber et al. 1982). Self induction of 2,3,7,8-TCDD metabolism was reported in both species (Poiger and Schlatter 1985 Weber et al. 1982). A single 10 g/kg dose of unlabeled 2,3,7,8-TCDD... 

Metabolism of TCDD. No metabolites of TCDD have been identified so far. It has recently been reported by Guenthner et al.(20) that TCDD can be metabolized by the mouse liver cytochrome P-U50 system to reactive intermediates, which easily bind covalently to cullular proteins. It is suggested that this extreme reactivity inhibits the formation of normal metabolites like phenols, dihydrodiols, or conjugated products. ... 

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