Conjugation overview

Figure 9-1. Materials overview a few sclcclcd conjugated polymers and Ihcir properties have been compiled and ihe following abbreviations arc used DO-PPP...Poly(2-decyloxy-l,4-phcnylcnc), EHO-PPP...Poly(2-(2 -elhylliexyloxy)-l,4-phcnylenc), CN-PPP... Poly(2-(6 -cyano-6 -incthyl-licplyloxy)-l,4-phcnylene), m-LPPP... methyl-substituted ladder-type Poly( 1,4-phenylcne), and PLQY=phololuinincs-ecncc quanluni yield.

The following methods are generalized to provide an overview of how SPDP can be used in these conjugation techniques. The appropriate optimization for a particular toxin conjugate should be done. 

The following sections discuss the main techniques used to make (strept)avidin conjugates and various biotinylated components. Chapter 11 and Chapter 18, Section 3 should be consulted for a complete overview of biotinylation reagents. 

Wilbur, D.S. (1992) Radiohalogenation of proteins An overview of radionuclides, labeling methods, and reagents for conjugate labeling. Bioconjugate Chem. 3, 433-470. 

Dibromoethane is metabolized to active forms capable of inducing toxic effects by either of two systems-the microsomal monooxygenase system (cytochrome P-450 oxidation) and the cytosolic activation system (glutathione conjugation). Figure 2-3 provides an overview of the metabolism of... 

Figure 11.4. Overview of drug molecules that have been incorporated into drug targeting that are discussed in Section 11.5.1. The functional group of the drug molecule that is used for conjugation to the carrier has been high lighted.

Overview of Semi-Empirical and Ab Initio Molecular Orbital Methods. 2.2 Applications of Molecular Mechanics. 3 Experimental Structural Methods. 3.1 X-Ray Diffraction. 3.2 NMR Spectroscopy and. 3.3 Mass Spectrometry. 3.4 UV/Fluorescence. 3.5 IR Spectroscopy. 3.6 Redox Potentials. 4 Thermodynamic Aspects. 4.1 Melting Points. 5 Reactivity of Fully Conjugated Rings 6 Reactivity of Nonconjugated Rings... 

The overview of HPMA copolymer-anticancer drug conjugates and their antitumor activities can be found in Table 1. As with other carrier systems, attachment of an anticancer drug to the HPMA copolymer carrier changes the drug s pharmacokinetics. For example, ADR attached to HPMA copolymers via a Gly-Phe-Leu-Gly sequence showed a 15-times longer intravascular half-life and a 100-fold lower initial peak level in the heart tissue when compared to free... 

The conjugative properties of a cyclopropane have been examined extensively. Early work in this area has been reviewed by Charton40, Story and Clark17, de Meijere41 and an extensive overview of more recent work has been prepared by Tidwell42. Recent updates on this topic have been provided by Cremer and colleagues26,43,44. 

This volume focuses on extensions of peptide chemistry into the novel areas of template-conjugated peptides, helical arrays of polypeptides, dendrimers, and C-terminally modified peptides. The volume concludes with an overview of the classic syntheses of representative peptide natural products. 

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