Conjugation biomolecules

New strategies for the delivery of biomolecules have emerged with the discovery of cell penetrating peptides (CPP), which are small, generally basic amino acid-rich peptides that are internalized within most cell types. More importantly, they allow the cellular uptake of chemically conjugated biomolecules of various types, including ON, peptides or proteins (7,8). 

During the last few years numerous authors have postulated the frequent formation of charge-transfer complexes between molecules of biochemical interest and in particular conjugated biomolecules, rich in n electrons (which are known from general quantum chemistry to have smaller ionization potentials and greater electron affinities than saturated molecules) and have postulated the involvement of such complexes both in the mechanism of biochemical reactions and in the structure of certain cellular components (nucleic acids, mitochondria, quantosomes). 

The results of the theoretical evaluation of the electron-donor and -acceptor abilities for a number of compounds representing the essential groups of conjugated biomolecules are illustrated in Table IV. They lead to the conclusion that from that point of view conjugated biomolecules may be divided into three main groups ... 

Model Systems for Dynamics of 7T-Conjugated Biomolecules in Excited States... 

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