Congenital heart block, neonatal lupus

Although an association between maternal connective tissue disease and cardiac involvement in neonatal lupus was suspected as early as 1901 (M22), the association between skin disease in an infant and maternal autoimmune disease was not reported until more than 50 years later. McCuistion and Schoch (M13) described an infant with a scaly erythematosus rash whose mother had systemic lupus erythematosus. The typical association of maternal antibodies to Ro/SSA was described for congenital heart block (CHB) several decades later in 1983 (R5, S8). 

A14. Alexander, E., Buyon, I. P., Provost, T. T., and Guamieri, T., Anti-Ro/SS-A antibodies in the pathophysiology of congenital heart block in neonatal lupus syndrome, an experimental model. In vitro evectrophysiologic and immunocytochemical studies. Arthritis Rheum. 35, 176—189 (1992). 

B33. Buyon, J. P., Hiebert, R., Copel, J., Craft, J., Friedman, D., et al., Autoimmune-associated congenital heart block Demographics, mortality, morbidity and recurrence rates obtained from a national neonatal lupus registry. J. Am. Coll. Cardiol. 31, 1658-1666 (1998). 

B36. Buyon, J. P., Winchester, R. J., Slade, S. G., Arnett, F., Copel, J., eta .. Identification of mothers at risk for congenital heart block and other neonatal lupus syndromes in their children. Comparison of enzyme-linked immunosorbent assay and immunoblot for measurement of anti-SS-A/Ro and anti-SS-B/La antibodies. Arthritis Rheum. 36, 1263—1273 (1993). 

L7. Lawrence, S., Luy, L., Laxer, R., Krafchik, B., and Silverman, E., The health of mothers of children with cutaneous neonatal lupus erythematosus differs from that of mothers of children with congenital heart block. Am. J. Med. 108, 705—709 (2000). 

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