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Conformational changes recognition

Substrates and enzymes induce mutual conformational changes in one another that facihtate substrate recognition and catalysis. [Pg.59]

A more subtle example of homochiral preference, which draws attention to the conformational changes in the molecules needed to achieve self-recognition, is that... [Pg.21]

Antigen antibody recognition is dependent on protein structure. A conformational change in a protein caused by formalin fixation may mask the epitope and thus affect the antigenicity of proteins in formalin-treated tissue (Montero 2003). The antigen retrieval leads to a renaturation or at least partial restoration of the protein structure, with re-establishment of the three-dimensional protein structure to something approaching its native condition (Shi et al. 1991). [Pg.48]

Cusack, S., Yaremchuk, A., and Tukalo, M. (1996). The crystal structures of T. thermophilus lysyl-tRNA synthetase complexed with E. coli tRNA(Lys) and a T. thermophilus tRNA (Lys) transcript anticodon recognition and conformational changes upon binding of a lysyl-adenylate analogue. EM BO J. 15, 6321—6334. [Pg.271]

The basic principle of this method of recognition is a cation-induced conformational change bringing closer together (or moving away) two moieties able to interact and induce photophysical effects excimer or exciplex formation (or disappearance), electronic energy transfer and quenching. [Pg.37]

Recently it was shown that introduction of fluorescent groups into ionophoric calix[4]arenes provides new systems for recognition of alkali metal ions.<59 62) Because of the mobility of the phenyl units, conformational changes can be induced by solvents and metal ions. Examples are given in Figure 2.15. [Pg.40]

The initial event is the binding of ferri-heme to hemopexin in the plasma, which induces a conformational change in the protein and enables high-affinity molecular recognition by cells expressing the... [Pg.233]


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See also in sourсe #XX -- [ Pg.318 ]




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