Confirmation Analysis of Dioxins and Dioxin-like PCBs

Confirmation Analysis of Dioxins and Dioxin-like PCBs 

Keywords dioxin PCDD PCDF dioxin-like PCB TEF TEQ WHO screening confirmation HRGC/HRMS accurate mass MID 

Over the past 30 years, dioxin TEQ levels and body-burden levels in the general population have been on the decline and continue to decrease (Lorber, 2002). But, more than 90% of human exposure to dioxins and dioxin-like substances is through food, mainly meat and dairy products, fish and shellfish, and hence lead to continuous control (WHO 2014). With increasingly lower dioxin levels in food, feed and tissues, more demanding LOD, selectivity, sensitivity and QC checks are required to trace their presence at these further decreasing levels. 

The described isotope dilution method for the quantification of polychlorinated dioxins, furans and dioxin-hke polychlorinated biphenyls (dl-PCBs) follows the EPA 1613 Rev.B method (US EPA, 1994,1998a/b). The MID scheme on the accurate target masses typically uses isotope ratio qualifiers besides the specific retention time for all native dioxin/furan congeners, as well as for their specific labelled internal standards, one quantification mass and one ratio mass. The analytical setup for the high resolution GC-MS is given with the MID descriptor, as 

Sample material Food, meat eggs, milk, blood, and so on 

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Confirmation Analysis of Dioxins and Dioxin-like PCBs I 703... 

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