Cone-voltage fragmentation compared with

The effect of inducing fragmentation by collisional activation can also be achieved through collision with solvent molecules in the API ion source. Various implementations of this procedure are called up-front CID, cone voltage fragmentation and poor man s MS-MS. Results obtained this way are comparable to true MS-MS product ion spectra. The strict interpretation of the results in terms of precursor-product ion relationships is lost, but this limitation does not negate the utility of the method when a true tandem instrument is not available. 

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