Condensation, of cyclohexanone and

Cyclohexylidenecyanoacetic acid has been prepared by the condensation of cyclohexanone and cyanoacetic acid in the presence of piperidine 4-5 and by the hydrolysis of ethyl cyclohexyl-idenecyanoacetate.4... 

Cyclohexenylacetonitrile has been prepared by the decarboxylation of cyclohexylidenecyanoacetic acid 4-5 by the dehydration of 1-cyclohexenylacetamide 5 by the condensation of cyclohexanone and cyanoacetic acid in the presence of piperidine 6 by the condensation of cyclohexanone and ethyl cyano-acetate in the presence of sodium ethoxide 4-7 and by the condensation of cyclohexanone and cyanoacetic acid in the presence of ammonium acetate followed by decarboxylation.8 Ammonium acetate also has been used as a catalyst for the condensation of ketones with ethyl cyanoacetate.3-9... 

Aldol-Like Self-Condensation of Cyclohexanone and its Dehydrogenation 110... 

A study of the Knoevenagel condensation of cyclohexanone and benzaldehyde with three active-methylene components showed that rubidium fluoride and cesium fluoride are more effective catalysts than potassium fluoride and that lithium fluoride... 

Rates for competing processes such as self-condensation of cyclohexanone and Cannizzaro or Tishchenko reactions of benzaldehyde are negligible compared with the Claisen-Schmidt condensation of aldehyde with ketone. 

Here is an example. Aldol condensation of cyclohexanone and benzaldehyde gives pure E alkene for the reasons explained above. Irradiation with longer-wavelength UV light equilibrates this to the Z alkene in excellent yield. 

Lastly, Atta-ur-Rahman and Firdous were able to generate a 21-carbomethoxy yohimbane derivative by a one-step appendage of the DE-rings to a jS-carboline derivative (Scheme 3.77) (126). Methoxy substituted j8-carboline 391 was treated with bis-anhydride 441, prepared by condensation of cyclohexanone and oxalyl chloride, to afford pentacyclic zwitterionic substance 442 or 443, depending on the alcoholic solvent employed. Reduction of 442 afforded the pentacyclic enamine 444 in addition to 445, whereas reduction of the corresponding ethyl ester 443 provided 446 and 447. 

Aminopropylated functionalized hexagonal mesoporous silicas (HMS) and SBA-15 materials with different amino-loadings (5-30 wt. % NH ) were synthesized by Pineda et al. (2013). These play important role as catalyst in the microwave-assisted Knoevenagel condensation of cyclohexanone and ethyl cyanoacetate as well as in the Michael reaction between 2-cyclohexen-l-one and nitromethane. The low loaded HMS-5%NH2 and higher loaded SBA-15-20% NH were found to give the best activities in the reactions. High activities and selectivities to the condensation product could be achieved in short times of microwave irradiation for both these base-catalyzed processes. 

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