Concluding Remarks and Unanswered Questions

0-DimethyUiydroxylamine hydrociloride (75) (11.46 g, 117.5 mmol) and sodium acetate are dissolved in water (28 ml) and slowly added to a solution of 2-acetamido-2-deoxy-D-glucose (70) (10 g, 45.2 mmol) in water (38 ml) at 0 °C. The reaction mixture is stirred for 20 h at room temperature, after which the complete conversion can be observed by the appearance of a faster moving spot on a silica plate TLC (DCM MeOH = 5 1, i f = 0.4). The solvent is removed in vacuo, and the crude solid is purified by flash sihca gel column chromatography (DCM MeOH = 8 1), yielding a white crystalline solid (76) (11.35 g, 42.95 mmol, 95%). 

Nuclear factor kappa-light-chain-enhancer of activated B cells N-Hydroxysuccinimide Nuclear magnetic resonance Nodulation 

Acid dissociation constant Poly(amido amine) 

Reversible addition-fragmentation chain transfer Surface plasmon resonance Thin layer chromatography 

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