Concepts of Chemoenzymatic Processes

Cascade Biocatalysis Integrating Stereoselective and EnvironmerOaVy Friendly Reactions, First Edition. 

Edited by Sergio Riva and Wolf-Dieter Fessner. 

In the following, we give an overview on the research developments referring to both types of concepts, that is, concept (a) or concept (b). Although this review will also describe key historical developments in the field, the major focus will be on more recently developed synthetic examples. Thus, this review should be considered as an extension of previous overviews on chemoenzymatic syntheses described earher with a different focus by, for example, Kieboom et al. [3], Faber et al. [4], BackvaU et al. [5, 6], and Pellisier [7]. 

Combination of Substrate Isomerization and their Derivatization with Chemo- and Biocatalysts Resulting in Dynamic Kinetic Resolutions and Related Processes 

The first broadly applicable and highly practical type of DKR of alcohols in organic media was developed by the Backvall group [13, 14] by using the Shv6 ruthenium complex 14 as an efficient and enzyme-compatible metal-based redox catalyst for in situ racemization of alcohols. Notably, this (nonchiral) ruthenium catalyst does not require base and ketone additives for efficient racemization. This racemization 

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