Computational modeling tertiary protein structure

J. R. Gunn, A. Monge, R. A. Friesner, and C. H. Marshall, /. Phys. Chem., 98,702 (1994). Hierarchical Algorithm for Computer Modeling of Protein Tertiary Structure Folding of Myoglobin to 6.2 A Resolution. 

Hierarchical Algorithm for Computer Modeling of Protein Tertiary Structure Folding of Myoglobin to 6.2 A Resolution. 

Three-dimensional molecular modelling of proteins has become feasible with the advent of powerful computers. For purified proteins whose primary sequence is known, and whose X-ray crystallographic structure is unknown, these techniques can be useful for elucidating the tertiary structure. For example, Kumosinski et al. (1991) have proposed 3-D molecular models for the bovine caseins. Especially when used in conjunction with other techniques such as spectroscopic results, this approach can yield useful clues to the relationships between structure and function. 

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