Compounds with activated halogen atoms

Compounds with activated halogen atoms, e.g., 7-chloro-4-nitrobenzo-furoxan (234), undergo displacement reactions with a variety of nucleophiles, including sulfides,300 443,444 amines,300,443,491 phenoxides,300 and others mentioned earlier.6 Sometimes rearrangements of the type discussed in Section V,C,4 occur, leading to products other than those of simple displacement.300,443 When 7-chloro-4-nitrobenzofuroxan is treated with an aryl-sulfinate, both substituents are replaced, and the 4,7-bisarylsulfonyl compound is formed. One of the arylsulfonyl groups is, in its turn, susceptible to replacement by other nucleophiles.444... 

The electrophilically active substances have as toxophoric constituent an electrophilic group which is responsible for the antimicrobial effect, because it enables these active substances to react with specific nucleophilic entities of the microbial cell (Paulus, 1993) Examples of this class are aldehydes [II, 2.], e.g. Glutaraldehyde, compounds with activated halogen atoms [II, 17.], e.g. Bronopol, and microbiocides with an activated S-N-bond [II, 15.], for example Isothiazolinones. Since Isothiazolinones represent a major class of bactericides for industrial preservation, much research has been performed in this area. 

Compounds with activated halogen atoms, e.g. l,2-dibromo-2,4-dicyanobutane (DBDCB) [II, 17.16.] and 2-bromo-2-nitropropane-l,3-diol (Bronopol) [II, 17.14.]... 

Alcohols - Aldehydes Aldehyde releasing compounds - Phenol derivatives Adds - Add esters - Amides Carbamates -Dibenzamidines Pyridine derivatives Azoles Heterocyclic N, S compounds - Compounds with activated halogen atoms - Surface-active agents OrganometalUc compounds - Various compounds Chddidng agents... 

The hydroxymethylated nitro-hydrocarbons disposing of an activated halogen are described under 17. Compounds with activated halogen atoms . 

The pyridine derivative 2,3,5,6-tetrachloro-4-(methylsulphonyl)pyridine appropriately is listed under 17. Compounds with Activated Halogen Atoms . 

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