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Compound properties intestinal permeability

Fagerholm, U., Lindahl, A., Lennernas, H., Regional intestinal permeability in rats of compounds with different physicochemical properties and transport mechanisms, /. Pharm. Pharmacol. 1997, 49, 687-690. [Pg.183]

An important DMPK property of a NCE is oral bioavailability (F) of the compound in various pre-clinical species.3 The oral bioavailability of a compound is dependent on several factors including intestinal permeability (estimated by the Caco-2 assay) and hepatic clearance (estimated with an in vitro metabolic stability assay).3 30 The metabolic stability assay is typically performed by incubating test compounds in liver microsomes or hepatocytes. The results can provide estimates of in vivo stability in terms of metabolic liabilities.3 8 59 62 Several authors described this assay as an important tool for the rapid assessment of the DMPK properties of NCEs.3 6 8111819 26 44 59 62-65... [Pg.209]

Fagerholm U, Lindahl A and Lennernas H (1996b) Regional Intestinal Permeability for Compounds with Different Physico-Chemical Properties and Transport Mechanisms in Rats. Eur J Pharm Sci 4 pp 153. [Pg.71]

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See also in sourсe #XX -- [ Pg.6 , Pg.484 ]



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Compounding permeability

Intestinal permeability

Intestinal properties

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Permeability properties

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