Complexation in DNA

Figure 8. Intercalative covalent binding to N2(G). Trans BPDE-adducts are bound to the 5 side of G in the +G C,C G,BPT,C G,C G+ complex in DNA kinked to site KMa.

Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Cell 102 463-473... 

These reagents can be used either catalytically, by application of a potential of 0.8 V to a solution of Ru(tpy)(bpy)OH22+ or stoichiometrically, by isolation of the Ru(tpy)(bpy)02+ or Ru(tpy)(bpy)OH2+ complexes and addition of these reagents to a DNA solution. The chemistry of these complexes in DNA will be discussed in detail in this chapter. 

The interaction of tilorone hydrochloride to DNA encouraged us to study the template activity of the complexes in DNA- and RNA- polymerase systems from E. coli. Both the activities were found to be inhibited by tilorone the DNA polymerase reaction being more sensitive towards tilorone. The inhibition of the RNA-polymerase reaction by tilorone was dependent on the A-T content of DNA-template. The template activity of poly (dA-dT) in the RNA polymerase reaction is distinctly more sensitive towards tilorone than that of DNA particularyly, at low drug concentrations the poly (dA-dT)-catalyzed reaction was three times more sensitive than the DNA-catalyzed activity of RNA polymerase reaction60. ... 

Wang, Z. and Rana, T.M. (1997) DNA damage-dependent transcriptional arrest and termination of RNA polymerase II elongation complexes in DNA template containing HIV-1 promoter. Proc. Natl. Acad. Sci. USA,... 

This complexity in DNA structure is in fact small compared to that of RNA. Figure 8.2C (see color plate section, page C-15) shows the first crystallograph-ically characterized structure of an RNA polymer, yeast tRNA . Ostensibly single-stranded RNAs do not exist as random coils, but instead fold up into well-defined three-dimensional structures, much like proteins. The structural variety, of course, bears some resemblance to that found in DNAs. Double-helical... 

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