Complex systems theory pathway stability

This system, however, is much more complex than the simple description in Figure 5.45 suggests. The proper analysis of such systems has to involve the Curtin-Hammett analysis of interconversion of reactive and unreactive conformers and the evolution of stereoelectronic effects along the interconnected reaction pathways. The critical examination of APL theory by Perrin also suggested that the role of conformational equilibria of reactive species, the involvement of syn-periplanar lone pairs, and the different stability of products should be included in the analysis. We will continue our discussion of cooperativity and anti-cooperativity between stereoelectronic effects in Chapter 11. 

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