Compartmental Models and Heterogeneity

Boundary and initial conditions are considered as discussed above. 

The model was used to identify indocyanine green profile in man after qo = 10 mg intravenous bolus injection. Both injection and sampling sites (zq and z, respectively) were closely located on the ring-shaped tube. The model of drug administration was a thin Gaussian function  

This administration corresponds to a bolus injection at the cephalic vein. The parameters set in the model were m = 3, /r0 = 50 cm, Aq = 3 cm2, and b = 105. The estimated model parameters were  

Initially, the deterministic theory was applied to describe the movement of a population of tracer molecules. Briefly, a drug administered as a bolus input into an 

compartmental models have been used extensively in the pharmacokinetic literature for some time, but not without criticism. These criticisms were directed  

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