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Compactin microbial oxidation

Production of the cholesterol-reducing pravastatin (29) by oxidation of compactin (28) catalyzed by a P450 monooxygenase from Mucor hiemalis (Daiichi Sankyo Inc., USA, and Bristol-Myers Squibb, USA) is another example of a commercial application of microbial oxidations [90, 91] (Scheme 12.9). The same reaction can be catalyzed by Streptomyces sp. Y-110. In a batch culture with continuous feeding of compactin into the culture medium a conversion rate of 15 mg h pravastatin... [Pg.432]

See other pages where Compactin microbial oxidation is mentioned: [Pg.77]    [Pg.77]    [Pg.567]   
See also in sourсe #XX -- [ Pg.77 ]

See also in sourсe #XX -- [ Pg.77 ]

See also in sourсe #XX -- [ Pg.7 , Pg.77 ]

See also in sourсe #XX -- [ Pg.7 , Pg.77 ]

See also in sourсe #XX -- [ Pg.77 ]



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