Commercial resources

Individual blood samples are collected from all animals in various groups at the time of sacrifice. Blood is obtained via intracardiac stick under methoxyflu-rane anesthesia and collected into EDTA microtainers and Serum Separator microtainers for complete blood count (CBC) and serum chemistry evaluation, respectively. Clinical chemistry is performed by a commercial resource (e.g., ANTECH Diagnostics) (see Note 8). 

Figure 26.2 Public and commercial resources for the computational toxicology...

One of the first steps in the risk assessment process involves the collection of available information on the physicochemical properties, ecological effects, environmental fate, and health effects for a given chemical. In a nontesting strategy, data are also essential to make predictions by means of the read-across approach. Data can be retrieved from books, Internet-based resources (free and commercial resources), or commercial databases. This is a vast and rapidly developing field, so the reader is referred elsewhere for discussions of data sources [28-31],... 

Following the introduction presented in Chapter 1, this book discusses the application and use of specific analytical techniques (mass, infrared, and nuclear magnetic resonance spectrometry, chromatography, and capillary electrophoresis) in the combinatorial chemistry field (Chapters 2-6). It also discusses how to make sense of the vast amounts of data generated (Chapter 7), details how the actual libraries of compounds produced are utilized (Chapter 8), and lists some of the vast commercial resources available to researchers in the field of combinatorial chemistry (Chapter 9). 

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