Combretastatin bioactivity

Combretastatins, a series of bioactive stilbenes (combretastatin A series), bibenzyls (B series), phenanthrenes (C series), and macrocycUc lactone (D series), were obtained from the African wiUow tree Combretum caffrum (Combretaceae). Among them, the A series of combretastatins belonging to stilbenes, including combretastatins A-1 to A-6 2—7, are found to be tubulin polymerization inhibitors. 

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