Combining ’-scores

Similar considerations apply for running scores as apply to combination scores above. 

Apply qualitative WQE (see Section 10.5.1.2 and ATSDR 2004) is the combined score positive ... 

The specificity and sensitivity of each model is reported in the middle and bottom ofTable 13.1. In general, the models trained on only Scitegic fingerprints (Model FP) perform better than the other models. The combined score from Model FP and Model PG improve the prediction on the drug set which contains molecules chemically different that the test set and the training set. A relatively high enrichment was observed for both models although the selectivity model appears more accurate than the promiscuity model. 

Combined score = (score from Model PC 10) + score from Model FP... 

The combined score from the fingerprint and physicochemical models was the best to confirm a logical trend from lead optimization to launched drugs. Indeed, as shown in Figure 13.4, the best scored compounds were checked for the phase in which they belonged and the average scores suggested that, as a trend, compounds predicted as promiscuous are found more often in the lead optimization phase than... 

Figure 8.11 A multispectral wood image, (a) Pseudocolor image (b) Score plot (c) Multivariate image analysis (MIA) combined score image (d) Feedback Multivariate Model Selection (FEMOS) nine-class segmented image. Illustration reproduced from Ref [53].

Modified McGeoch s method and the cleavage-site consensus Amino acid composition of the N-terminal 20 residues and some weak cleavage site consensus Combined score for various empirical rules The KDEL-like motif at the C-terminus Motifs XXRR-like (N-terminal) or KKXX-like (C-terminal) PTS1 motif at the C-terminus and the PTS2 motif [TIK]LP[NKI] motif... 

Some work on consensus scoring in ligand-based virtual screening has indicated that much of the improvement from combining scores originates from the fact that different methods have different systematic errors [123]. It has also been shown on a theoretical basis that the combination of individual functions improves the enrichment of true actives only if each individual function is distinctive and has already a high performance [124]. 

Figure 5. a) Combined score plots of integrated spectroscopic data in "common CV1/CV2 space. 

Friedman s repeated measures ANOVA. Differences in vaginal marking across estrous cycle days (D2 vs. PE) were analyzed within each odor condition and on combined scores with Wilcoxon tests. Mann-Whitney tests were used to compare the marking scores of LOT and sham females within each odor condition and cycle day as well as on scores collapsed across estrous days and odor conditions. Flank marking scores were only analyzed (Mann-Whitney test) between groups as LOT females almost never marked in any of the conditions. 

Firm Function Average Combined Score Firm Function... 

Type of Industry Sectors Average Tool Usage Performance Impact Scores Average Firm Function Combined Score ... 

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