Combinatorial synthesis and screening

Methods for Combinatorial Synthesis and Screening of Large Numbers of MIPs... 

Capitalizing on self-assembly and nanoscience will enhance the ability to screen drugs for individual sensitivities. Advances in drug discovery, combinatorial synthesis, and screening with sensors that have the ability to detect multitudes of specific genetic matches—marrying microelectronics and self-assembly—are expected to be near-term breakthroughs. Then the creation of advanced forms of in the field or in the office tests for chemical risks, pharmaceutical compatibility, or environmental hazards will be possible. 

Ganesan, A. Strategies for the dynamic integration of combinatorial synthesis and screening. Angew. Chem. Int. Ed. 1998, 37, 2828-2831. 

Structural and compositional characterization of individual elements of a combinatorial library can be important for the initial validation of a particular combinatorial synthesis method. Many earlier reports on combinatorial synthesis and screening of electrocatalysts fall short of reporting the complete structural and compositional characterization of individual library elements of interest. The workflow described here includes catalyst characterization before and after screening, thereby establishing an activity-composition-structure-stability relationship for electrocatalysts. This can be relevant in light of the extreme conditions present in a conventional fuel cell environment. 

Combinatorial synthesis and screening of heterocyclic, drug-like scaffold libraries... 

Fig. 14.1 Hanak s representation of combinatorial synthesis and screening (Copyright (1970) Chapman and Hall Ltd reprinted with kind permission of Springer Science and Business Media1)...

Muskal, S. M. (1995) Exploiting data from combinatorial synthesis and screening. Abstr. Pap. Am. Chem. Soc. 210th, CINF-023. 

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