Combinatorial search

GROUPBUILD [68] fragment-based, sequential growth, combinatorial search ... 

Therefore, a good catalyst leads to weak fluorescence in the Heck product (15). A relatively small library of 96 known phosphines was tested in the palladium-catalyzed Heck coupling. Several sterically hindered ligands led to high catalyst activity. Fluorescence tags have also been used in the combinatorial search for metal-free catalysts in other types of reaction.42,43... 

Genetic Algorithm-Assisted Combinatorial Search for a new Green Phosphor for use in Tricolor White LEDs. 

There are two approaches to the discovery of enzyme mimics, i.e., to identify molecules that are able to bind substrate (s) and then catalyze reactions (Rowan, 1997). The first approach, often inspired by enzymes themselves, utilizes chemical knowledge and experience to design the catalyst The other approach is to create a library and select the best host for a transition-state analog of the required reaction. The second approach, i.e., the combinatorial search, is covered in Chapter 11 the first one is discussed below. This first approach, the finding of enzyme mimics, has been reviewed by Kirby (1996) and Reichwein (1994), among others. 

Similarly Mironov et al. described a novel method of combinatorial searching for... 

Afshar, M., Prescott, C.D., Varani, G. Structure-based and combinatorial search for new RNA-binding drugs. Curr. Opin. Biotechnol. 1999,10(1), 59. 

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