Combinatorial proteomic

To address this problem, recently a new strategy for proteome analysis has emerged. This technology, named Combinatorial Proteomic, uses antibody libraries as probes to profile the expression and function of protein families in complex proteomes. The use of antibodies allows the detection of iper- and ipo-expressed proteins, even if they are at pico-quantity level, overcoming one of the proteomic limitations of difficulty in detecting low abundance proteins [46, 47],... 

The striking feature of Combinatorial Proteomic is to exploit the natural antibody diversity in order to select specific antibodies with high avidity for selected protein families. 

Combinatorial Proteomic is a process with five main phases, shown in Figure 22.2 ... 

FIGURE 22.2 Schematic representation of steps involved in Combinatorial Proteomic . 

The number of sites in the array can be used for combinatorial purposes. Combinatorial experiments can be oriented to a diversity of applications, genomics, proteomics, and biochemical, in general. Molecular inversion and SNP Genotyping are well-proven uses of the technology. 

Although, MediChem is a biosecurity products manufacturer, its biotechnology-based R D capabilities are worth mentioning here. The attended markets include Medical, Laboratory, Veterinary, and Environmental sectors. Medicinal chemistry services and drug discovery form the basis of the company, though their capabilities might be applied in a broader range of sectors. These capabilities comprise the areas of Proteomics, Combinatorial and Computational Chemistry, Medicinal Chemistry, Enzymes, Process Development, Analytical and Separations Chemistry, Chemical Synthesis and Scale Up. 

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