Combinatorial libraries small organic molecule

Combinatorial approaches to the synthesis of libraries of peptides, nucleotides, and many classes of small organic molecules are well documented.35 However, the field of oligosaccharide combinatorial chemistry is still in its infancy.36 The slow development is due to the inherent complexities in the synthesis of oligosaccharides. 

Kibbey CE. Quantitation of combinatorial libraries of small organic molecules by normal-phase HPLC with evaporative light-scattering detection. Molecular Diversity 1, 247-258, 1996. 

Taylor EW, Qian MG, Dollinger GD. Simultaneous online characterization of small organic molecules derived from combinatorial libraries for identity, quantity, and purity by reversed-phase HPLC with chemiluminescent nitrogen, UV, and mass spectrometric detection. Anal Chem 1998 70 3339-3347. 

Solution Phase Combinatorial Libraries of Small Organic Molecules... 

This review will cover encoding techniques for small organic molecule pool libraries, one of the most challenging and powerful techniques in combinatorial chemistry. A short introduction to illustrate briefly the advantages in library encoding and to compare the method with other structure determination techniques will be given, but for a more detailed introduction the reader should look elsewhere in this book [1]. 

Seneci P, Direct deconvolution techniques for pool libraries of small organic molecules, Combinatorial Chemistry and Combinatorial Technologies Methods and Applications (Eds. Miertus S, Fassina G), 153-192, 2005, Chapter 8, this volume. 

In this chapter we will discuss not only the methods and techniques used for analysis of small-organic-molecule libraries but also the approaches for generation of these libraries, with the understanding that synthesis, analysis, and screening of combinatorial libraries are the integrated parts of combinatorial technology. 

---