Combinatorial libraries, high-throughput

Products/technologies The mixing routine of the FAMOS microsampling HPLC workstation enables automated method development for sample handling techniques of single beads to produce combinatorial libraries high-throughput is achieved by multiple analysis per vial. 

Zhang, W. 2007. Fluorous-enhanced multicomponent reactions for making drug-like library scaffolds. Combinatorial Chemistry High Throughput Screening, 10 219-29. 

Recently, with the use of combinatorial and high-throughput chemistry, more general types of structure representation, so-called chemical libraries, have become common (Fig. 

Solid-phase synthesis Polymer-supported synthesis Polymer-supported solution synthesis Tag-assisted solution synthesis Combinatorial chemistry High-throughput synthesis Library Microreactor... 

Products/technologies Protogene Laboratories focuses on a world scale approach to synthesis facilities on systems for synthesizing DNA on surfaces, and on combinatorial and high-throughput synthesis of drug libraries. 

Fig. 1. Schematic of the combinatorial experimental method, as applied to the preparation of thickness and temperature gradient film libraries, high throughput screening with optical microscopy, and informatic analysis of image data as a function of temperature, thickness, and time. Adapted with permission from Ref. 22.

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