Diversity combinatorial

Fig. 4.5. Combinatorial diversity in dihydropyrimidines synthesized via Biginelli condensation.

Cell-based partitioning can not only be used for compound selection but also to aid in combinatorial diversity design. In this case, a chemical descriptor space is defined and empty partitions are generated by binning. Test compounds are then enumerated on the computer based on reaction schemes and selected to evenly populate these partitions. 

With specific functionality built-in, each building block qualified as only one type of fitting. Vast combinatorial diversity, however, was made possible by an extensive range of building blocks that could satisfy each type. For example, any aryl, fused aryl or heteroaryl monoaldehyde could be utilized as a female terminal and any cyclic ketone with active a,a -methylene groups could constitute a rigid male-male union. 

Compounds generated by the combinatorial approach can be classified according to different aspects. One possible and meaningful attempt is to go for combinatorial diversity (Fig. 17.2) [3] by considering all conceivable organic molecules as a combinatorial space. The latter can be divided into an oligomeric and a monomeric space. It is important... 

Combinatorial diversity can be exploited in nature in the repertoire of antibodies with their remarkable combination of high affinity and selectivity and is also reflected in the conotoxins (159,160). 

Movement of Leukocytes into Tissues Depends on a Precise Sequence of Combinatorially Diverse Sets of Adhesive Interactions... 

All eukaryotic cells contain a lipid outer membrane composed of glycerolipids, sphingolipids and sterols. All three lipids have been found to exhibit a wide range of combinatorial diversity and their biochemical and biophysical properties determine functionality. 

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