Combinatorial chemistry Heck reaction

B.xiv.c. Intermolecular Heck Reactions on Polymeric Support. Combinatorial chemistry has initiated a reappraisal and consequent renaissance in synthesis of compounds attached to polymeric supports. Therefore, it comes as no surprise that Pd-catalyzed reactions are among the most widely explored reactions for the generation of combinatorial libraries on solid phase. The first example of the intermolecular Heck reaction on solid phase was reported in 1994. In this article, 4-vinylbenzoic acid was attached to Wang resin and coupled with aryl halides/triflates under catalysis with Pd(OAc)2 (Scheme 45). Similar... [Pg.1159]

The Mizoroki-Heck reaction is nearly predestinated to be used in solid-phase combinatorial chemistry. The commonly available substrates, the mild reaction conditions and the high yields combined with the ease and rapidity offered by combinatorial and parallel processes are at the origin of a lot of small-molecule libraries. [Pg.490]

The use of resin-bound substrates in combinatorial chemistry is often essential to creating diverse chemical libraries. Such polymer-supported reagents are suitable for Heck-type chemistry for example resin-bound iodobenzyl alcohol 88 was found to undergo reaction with a large range of... [Pg.20]