Combinatorial bioengineering

Ito et al (16) used combinatorial bioengineering methods to produce new biomaterials based on amino acids, nucleic acid, and non-natural components. In a different way, Silvestri et al (7) produced biomaterials by combining enzymes with synthetic polymers some examples were combinations of a-amylase with poly(vinyl alcohol), poly(ethylene glycol), and poly(hydroxyethyl methacrylate). Jong (9) used soy protein as a reinforcement material in elastomers and observed an increase in the rubber modulus. 

In their chapter, Ito et al (16) used combinatorial bioengineering, in which target molecules were selected from a random molecular library, to prepare functional polymers that had molecular recognition and catalysis capability. Other recent examples of where combinatorial methods have been applied to solve problems are given in Ref 78. 

Design and Synthesis of Biorelated Polymers by Combinatorial Bioengineering... 

Combinatorial bioengineering, in which targeting molecules are selected from a random molecular library, has been used to prepare functional polymers that have a molecular recognition and catalysis capability, and biodevice polymers based on these functionalities. Although the polymer content is limited to natural nucleic acids and amino acids, this has been extended to nonnatural compounds. The possibility of developing new functional polymers using combinatorial bioengineering is discussed. 

In the design of these polymer systems, combinatorial engineering is useful for creating functionalities. In the fiiture, the functional polymers discussed in this article will contribute to the production of nanodevices by combining nanotechnology with combinatorial bioengineering. 

Tricand de la Goutte, J Khan, JA Vulfson, EN. Identification of novel polyphenol oxidase inhibitors by enzymatic one-pot synthesis and deconvolution of combinatorial Mhidiiies. Biotechnology and Bioengineering, 2001 75, 93-99. 

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