Comb-Shaped Polymers with Peptide Blocks

3 Comb-Shaped Polymers with Peptide Blocks 

NCA polymerization allows also the preparation of comb-shaped polymers. Lu et al. reported the one-pot synthesis of comb-shaped polymers via ring-opening metathesis polymerization and NCA polymerization (Fig. 18). The authors used a norbomene derivative with a trimethylsilyl-protected amine to prepare a polymer with pendant trimethylsilyl amine groups, which can be used as initiators for the NCA polymerization (see. Fig. lb) [17]. 

Using 4-vinylbenzylamine hydrochloride as initiator for the NCA polymerization of ZLL-NCA, macromonomers were obtained, which could be copolymerized in a free-radical polymerization with glycidyl methacrylate [123] or W-isopropylacrylamide [124]. After deprotection of the PLL, the graft polymers show temperature- and pH-responsiveness and form micellar structures at pH 12 [124]. 

Although the degree of polymerization was very low for the polymerization of the macromonomers (grafting through), the grafting from was successful. Analysis of the resulting polymer indicated that every second amino group initiated a peptide 

---